See information below on IBS and this treatment. To create a Treatment Checklist, go to the bottom of the screen and enter your information in the four sections: 1) past or present use, 2) frequency and duration, 3) did this treatment work?, and 4) significant side effects. To see the next treatment either click on the treatment list at the bottom of the screen or click ‘Save and Continue to Next Treatment.’ Click ‘Submit (Done)’ to generate a list to print or email, to discuss with your physician.

Ondansetron (Zofran)

How it works:
Acts on specific serotonin receptors targeting nerves in the intestinal tract. These nerves are responsible for bowel function.
Which symptoms it helps:
Diarrhea.
How long it takes to see a benefit:
Within one week.
Who may benefit:
IBS-D, especially individuals with nausea.
FDA approved:
N/A
Dosage:
4-8mg tablet or oral disintegrating tablet.
Special considerations or risks:
Individuals should be monitored for cardiac conduction abnormalities as well as serotonin syndrome, especially among individuals taking serotonergic drugs. Monitor for decreased bowel activity, especially among individuals with risk factors for gastrointestinal obstruction.
Most common side effects:
Constipation.

Recommendation:
No current recommendation from ACG

Recommendation:
NONE
Quality of Evidence:
NONE
Level of Evidence:
Ø
Past and Present Use Frequency and Duration Did this treatment work? Significant Side Effects
Past Use   Present Use   Yes   No   N/A