See information below on IBS and this treatment. To create a Treatment Checklist, go to the bottom of the screen and enter your information in the four sections: 1) past or present use, 2) frequency and duration, 3) did this treatment work?, and 4) significant side effects. To see the next treatment either click on the treatment list at the bottom of the screen or click ‘Save and Continue to Next Treatment.’ Click ‘Submit (Done)’ to generate a list to print or email, to discuss with your physician.

Eluxadoline (Viberzi®)

How it works:
Acts on specific opioid receptors targeting nerves in the intestinal tract. These nerves can sense pain and are responsible for bowel function.
Which symptoms it helps:
Overall IBS symptoms, abdominal pain, diarrhea.
How long it takes to see a benefit:
Within one week.
Who may benefit:
IBS-D
FDA approved:
IBS-D
Dosage:
75-100mg tablet.
Special considerations or risks:
This treatment is contraindicated among individuals without a gallbladder or who have a history of sphincter of Oddi problems, pancreatitis, alcohol abuse, alcohol addiction, who drink more than 3 alcoholic drinks a day, or have severe liver problems.
Most common side effects:
: Constipation is most common. Severe abdominal pain from sphincter of Oddi spasm or acute pancreatitis is a rare but potentially serious side effect.

Recommendation:
ACG suggests eluxadoline for overall symptom improvement in IBS-D patients who do not have a listed contraindication.

Recommendation:
WEAK
Quality of Evidence:
MODERATE
Level of Evidence:
√
Past and Present Use Frequency and Duration Did this treatment work? Significant Side Effects
Past Use   Present Use   Yes   No   N/A