See information below on IBS and this treatment. To create a Treatment Checklist, go to the bottom of the screen and enter your information in the four sections: 1) past or present use, 2) frequency and duration, 3) did this treatment work?, and 4) significant side effects. To see the next treatment either click on the treatment list at the bottom of the screen or click ‘Save and Continue to Next Treatment.’ Click ‘Submit (Done)’ to generate a list to print or email, to discuss with your physician.

Plecanatide (Trulance®)

How it works:
It works by increasing secretion of fluid into the intestines which helps in the passing of stool. It also calms pain-sensing nerves in the intestinal tract.
Which symptoms it helps:
Overall IBS-C symptoms, constipation, belly pain, bloating.
How long it takes to see a benefit:
Benefits for bowel habits in 1-2 weeks. Benefits for belly pain and bloating may take longer.
Who may benefit:
IBS-C
FDA approved:
IBS-C
Dosage:
3 mg
Special considerations or risks:
Cannot be given to those less than 18 years of age or those who have a bowel blockage.
Most common side effects:
Diarrhea

Recommendation:
ACG recommends plecanatide for overall symptom improvement in IBS-C patients.

Recommendation:
STRONG
Quality of Evidence:
MODERATE
Level of Evidence:
√
Past and Present Use Frequency and Duration Did this treatment work? Significant Side Effects
Past Use   Present Use   Yes   No   N/A