Selective Serotonin Re-uptake Inhibitors (SSRIs)
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How it works: Acts on serotonin levels in nerves within the gastrointestinal tract, spinal cord, and brain to improve abdominal and bowel symptoms. |
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Which symptoms does it help: Overall IBS symptoms. They accelerate GI transit and therefore may improve symptoms of constipation as well. |
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How long it takes to see a benefit: 2-4 weeks. |
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FDA approved: N/A |
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Dosage: The dose varies between SSRIs. |
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Special considerations or risks: Serotonin syndrome could happen as the result of drug interactions with monoamine oxidase inhibitor medications. Abrupt discontinuation of SSRIs may precipitate dizziness, gastrointestinal distress, fatigue, chills, and body ache. |
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Most common side effects: Insomnia, drowsiness, dry mouth, sexual dysfunction, and weight gain. |
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Recommendation: There is currently no recommendation from the ACG to support the use of SSRIs to treat IBS. |
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