Polyethylene Glycol (PEG)
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How it works: PEG is an osmotic laxative which causes water to be released into the bowel. PEG softens the stool without interfering with the active absorption of nutrients or electrolytes. |
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Which symptoms does it help: Consistency and frequency of bowel movements. Little to no effect on pain or bloating in IBS-C patients. |
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How long it takes to see a benefit: It may take 2 to 4 days for the PEG to produce a bowel movement. It works best when used between one and two weeks. |
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FDA approved: Constipation. |
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Dosage: 17 grams daily. The dose is either measured by the dosing cup (or one heaping tablespoonful of powder) or the use of one sachet. |
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Special considerations or risks: Animal reproductive studies have not been performed with PEG, and it is not known whether PEG can cause fetal harm when administered to a pregnant woman, or can affect reproductive capacity. |
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Most common side effects: Abdominal cramping, diarrhea, bloating and flatulence. |
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Recommendation: While ACG does not recommend PEG for abdominal pain and bloating in IBS-C patients, PEG may be helpful for treating chronic constipation. |
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