Bile acid binders (cholestyramine (Questran), colestipol (Colestid), colesevelam (Welchol))
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How it works: By binding to bile acids in the GI tract, these medications prevent excess fluid secretion and motility in the colon that can lead to diarrhea. |
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Which symptoms does it help: Diarrhea. |
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How long it takes to see a benefit: As quickly as one week but it can take several weeks to find the right dose. |
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FDA approved: N/A |
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Dosage: The dose of bile acid binders varies based upon the specific medication (cholestyramine, colestipol, colesevelam). |
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Special considerations or risks: Other oral medicines should not be taken at or around the time of taking the bile acid binders. Bile acid binders can prevent the absorption of other medications. |
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Most common side effects: Constipation, gas, bloating, nausea and vomiting. |
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Recommendation: While the ACG does not suggest the use of bile acid binders to treat overall IBS-D symptoms, they can be helpful in treating diarrhea. |
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