How it works: Acts on specific serotonin receptors targeting nerves in the intestinal tract. These nerves can sense pain and are responsible for bowel function.

Which symptoms does it help: Overall symptoms in women with IBS-C, constipation, belly pain.

How long it takes to see a benefit: 1-2 weeks.

FDA approved: Women with IBS-C under the age of 65 years.

Dosage: 6 mg twice a day.

Special considerations or risks: Contraindicated with a history of cardiovascular (MI or angina) or cerebrovascular (stroke or TIA) disease, history of ischemic colitis, severe renal impairment, moderate to severe liver impairment.

Most common side effects: Headache, abdominal pain.

Recommendation: No current recommendation from ACG