Linaclotide (Linzess®)
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How it works: It works by increasing secretion of fluid into the intestines which helps in the passing of stool. It also calms pain-sensing nerves in the intestinal tract. |
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Which symptoms does it help: Overall IBS-C symptoms, constipation, belly pain, bloating. |
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How long it takes to see a benefit: Benefits for bowel habits within 1 week. Benefits for belly pain and bloating may be seen in as little as 1 week but maximum benefit may take longer. |
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FDA approved: IBS-C |
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Dosage: 72 mcg*, 145 mcg*, 290 mcg (*are FDA approved for CIC not IBS-C) |
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Special considerations or risks: Cannot be given to those less than 18 years of age or those who have a bowel blockage. |
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Most common side effects: Diarrhea. |
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Recommendation: ACG recommends linaclotide for overall symptom improvement in IBS-C patients. |
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