Eluxadoline (Viberzi®)
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How it works: Acts on specific opioid receptors targeting nerves in the intestinal tract. These nerves can sense pain and are responsible for bowel function. |
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Which symptoms does it help: Overall IBS symptoms, abdominal pain, diarrhea. |
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How long it takes to see a benefit: Within one week. |
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FDA approved: IBS-D |
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Dosage: 75-100mg tablet. |
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Special considerations or risks: This treatment is contraindicated among individuals without a gallbladder or who have a history of sphincter of Oddi problems, pancreatitis, alcohol abuse, alcohol addiction, who drink more than 3 alcoholic drinks a day, or have severe liver problems. |
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Most common side effects: : Constipation is most common. Severe abdominal pain from sphincter of Oddi spasm or acute pancreatitis is a rare but potentially serious side effect. |
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Recommendation: ACG suggests eluxadoline for overall symptom improvement in IBS-D patients who do not have a listed contraindication. |
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