Eluxadoline (Viberzi®)


How it works: Acts on specific opioid receptors targeting nerves in the intestinal tract. These nerves can sense pain and are responsible for bowel function.

Which symptoms does it help: Overall IBS symptoms, abdominal pain, diarrhea.

How long it takes to see a benefit: Within one week.

FDA approved: IBS-D

Dosage: 75-100mg tablet.

Special considerations or risks: This treatment is contraindicated among individuals without a gallbladder or who have a history of sphincter of Oddi problems, pancreatitis, alcohol abuse, alcohol addiction, who drink more than 3 alcoholic drinks a day, or have severe liver problems.

Most common side effects: : Constipation is most common. Severe abdominal pain from sphincter of Oddi spasm or acute pancreatitis is a rare but potentially serious side effect.

Recommendation: ACG suggests eluxadoline for overall symptom improvement in IBS-D patients who do not have a listed contraindication. (Recommendation: weak; Quality of evidence: moderate).