Lubiprostone (Amitiza®)
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How it works: Activates a channel on intestinal cells that causes secretion of electrolytes and water which softens the stool and helps it to pass through the intestines and colon. |
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Which symptoms does it help: Overall IBS-C symptoms, constipation, belly pain, bloating. |
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How long it takes to see a benefit: Within 1-2 weeks. |
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FDA approved: Adult women with IBS-C, adults with chronic constipation, adults with opioid induced constipation |
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Dosage: 8 and 24 mcg twice daily. The recommended dose is 8 mcg twice daily in patients with IBS-C, and 24 mcg twice daily for patients with chronic idiopathic constipation and opioid induced constipation. |
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Special considerations or risks: Patients with liver disease are at increased risk for adverse reactions and dose adjustment for patients with moderate or severe liver disease may be required. Pregnancy: There is insufficient data on Lubiprostone use in pregnancy. Animal studies did not show an increase in structural malformations. |
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Most common side effects: Nausea, diarrhea, and abdominal pain. |
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Recommendation: ACG recommends lubiprostone for overall symptom improvement in IBS-C patients. |
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