Plecanatide (Trulance®)


How it works: It works by increasing secretion of fluid into the intestines which helps in the passing of stool. It also calms pain-sensing nerves in the intestinal tract.

Which symptoms does it help: Overall IBS-C symptoms, constipation, belly pain, bloating.

How long it takes to see a benefit: Benefits for bowel habits in 1-2 weeks. Benefits for belly pain and bloating may take longer.

FDA approved: IBS-C

Dosage: 3 mg

Special considerations or risks: Cannot be given to those less than 18 years of age or those who have a bowel blockage.

Most common side effects: Diarrhea

Recommendation: ACG recommends plecanatide for overall symptom improvement in IBS-C patients. (Recommendation: strong; Quality of evidence: moderate).